Friday, November 6, 2015

Possible evidence of alternate, parallel universes

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An astrophysicist says he may have found evidence of alternate or parallel universes by looking back in time to just after the Big Bang more than 13 billion years ago.

While mapping the so-called "cosmic microwave background," which is the light left over from the early universe, scientist Ranga-Ram Chary found what he called a mysterious glow, the International Business Times reported.

Chary, a researcher at the European Space Agency's Planck Space Telescope data center at CalTech, said the glow could be due to matter from a neighboring universe "leaking" into ours.
Multi-panel image showing the evolution of the data processing from the frequency
maps to the final result at the location



The thick line and diamonds indicate the spectrum of a 4◦ spot at (l, b = 83.6◦, −69.4◦) where the SNR of the residual 143 GHz emission is greater than 5 and where the 143 GHz emission is in excess of the residual at 100 and 217 GHz.

Arxiv - Spectral Variations of the Sky: Constraints on Alternate Universes (25 pages)

The properties of our observable Universe have recently been characterized in unprecedented detail through analysis of the cosmic microwave background fluctuations, a relic of the hot Big Bang. The fine tuning of parameters in the early Universe required to reproduce our present day Universe suggests that our Universe may simply be a region within an eternally inflating super-region. Many other regions beyond our observable Universe would exist with each such region governed by a different set of physical parameters than the ones we have measured for our Universe. Collision between these regions, if they occur, should leave signatures of anisotropy in the cosmic microwave background but have not yet been seen. Here, we analyze the spectral properties of masked, foregroundcleaned Planck maps between 100 and 545 GHz. We find convincing evidence for residual excess emission in the 143 GHz band in the direction of CMB cold spots which is well correlated with corresponding emission at 100 GHz. The median residual 100 to 143 GHz intensity ratio is consistent with Galactic synchrotron emission with a


spectrum. In addition, we find a small set of ∼ 2−4 degrees regions which show anomalously strong 143 GHz emission but no correspondingly strong emission at either 100 or 217 GHz. The signal to noise of this 143 GHz residual emission is at the

We assess different mechanisms for this residual emission and conclude that although there is a 30% probability that noise fluctuations may cause foregrounds to fall within 3σ of the excess, it could also possibly be due to the collision of our Universe with an alternate Universe whose baryon to photon ratio is a factor of ∼65 larger than ours. The dominant systematic source of uncertainty in the conclusion remains residual foreground emission from the Galaxy which can be mitigated through narrow band spectral mapping in the millimeter bands by future missions and through deeperobservations at 100 and 217 GHz.



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Evelo Therapeutics developing microbiome based cancer therapies

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Evelo Therapeutics is a new company focused on leveraging the power of the microbiome to develop novel therapies for cancer. It has with an initial capital commitment of $35 million.

Evelo is pioneering Oncobiotic™ therapeutics, a new modality in cancer therapy based on the cancer microbiome. Evelo is the first company to systematically identify, characterize and understand the biology of cancer-associated bacteria (CAB) and bacterial immune activators (BIAs™), providing new insights into cancer metabolism and immuno-oncology. The microbiome is the collection of trillions of microbes that live in and on the human body. In recent years, scientists have found that the microbiome plays a crucial role in many areas of human biology and disease.

Evelo’s Oncobiotic platform would treat cancer through unprecedented therapeutic modalities. Evelo’s novel approaches leverage tumor-microenvironment modifications that can be mediated by the microbiome to disrupt tumor metabolism and the interactions between the tumor and surrounding tissue.

This platform has four components:

1. Characterization of CAB and BIA™

2. A proprietary CAB database and computational biology platform yielding novel therapeutically relevant insights

3. Candidate optimization for specific cancer therapeutic activities

4. Proprietary in vitro and in vivo assay systems that uniquely focus on the CAB and BIA™ cancer interface


Evelo’s Oncobiotics are able to treat cancer through different mechanisms, including:
· Activation and priming of the immune system
· Disrupting the tumor microenvironment:
- by interfering with tumor metabolism
- by modifying the interaction of tumors with their surrounding cells and tissues (stroma)

The microbiome – the trillions of microbes that live on and within our body – plays a critical role in human biology and health.

Scientists are discovering the strong association between human cancers and the microbiome. Bacteria are found in most human cancers, reflecting the complex relationship between the underlying genetics of the patient and their microbiome.

The microbiome creates a specific microenvironment surrounding malignant tumors. Specific bacteria home to cancer cells and play supportive roles in tumor metabolism, tumor/cell interactions and protecting the tumor by suppressing the immune response.



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Concept ships by John Wallin Liberto

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95-year-old manse on Live Oak that couple hoped to turn into a wedding venue to be razed

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4901 Live Oak as it looked Tuesday, awaiting its inevitable demolition (Ron Baselice/Staff photographer) Same song, different verse: A Dallas house built in the early 20th century is coming down any day now. If 4901 Live Oak sounds at all … Continue reading
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This cabled, drawstr

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This cabled, drawstring pullover is called Harley and is part of the Knit Picks Twist & Tweeds 2015 Fall Collection.


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Editas will test CRISPR gene editing in humans by 2017

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Biotechnology startup Editas Medicine intends to begin tests of a powerful new form of gene-repair in humans within two years.

Speaking this week at the EmTech conference in Cambridge, Massachusetts, Editas CEO Katrine Bosley said the company hopes to start a clinical trial in 2017 to treat a rare form of blindness using CRISPR, a groundbreaking gene-editing technology.

If Editas’s plans move forward, the study would likely be the first to use CRISPR to edit the DNA of a person.

CRISPR technology was invented three years ago but is so precise and cheap to use it has quickly spread through biology laboratories. Already, scientists have used it to generate genetically engineered monkeys, and the technique has stirred debate over whether modified humans are next.

Editas is one of several startups, including Intellia Therapeutics and CRISPR Therapeutics, that have plans to use the technique to correct DNA disorders that affect children and adults. Bosley said that because CRISPR can “repair broken genes” it holds promise for treating several thousand inherited disorders caused by gene mistakes, most of which, like Huntington’s disease and cystic fibrosis, have no cure.

Editas picked the disease in part because it is relatively easy to address with CRISPR, Bosley said. The exact gene error is known, and the eye is easy to reach with genetic treatments. “It feels fast, but we are going at the pace science allows,” she said. There are still questions about how well gene-editing will work in the retina and whether side effects could be caused by unintentional changes to DNA.

Editas plans to deliver the CRISPR technology as a gene therapy. The treatment will involve injecting into the retina a soup of viruses loaded with the DNA instructions needed to manufacture the components of CRISPR, including a protein that can cut a gene at a precise location. Bosley said in order to treat LCA, the company intends to delete about 1,000 DNA letters from a gene called CEP290 in a patient’s photoreceptor cells.



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the last dip of the season by outofreception- schöne seele

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the last dip of the season by outofreception

- schöne seele


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An Eye-Opening Retinal Scanner

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The VISUSCOUT 100 delivers practical, high quality imaging for detection and monitoring of retinal disorders. Examinations are quickly performed and reviewed without needing to...
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New Charge Density wave found in superconductors

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A team led by scientists at the Department of Energy’s SLAC National Accelerator Laboratory combined powerful magnetic pulses with some of the brightest X-rays on the planet to discover a surprising 3-D arrangement of a material’s electrons that appears closely linked to a mysterious phenomenon known as high-temperature superconductivity.

This unexpected twist marks an important milestone in the 30-year journey to better understand how materials known as high-temperature superconductors conduct electricity with no resistance at temperatures hundreds of degrees Fahrenheit above those of conventional metal superconductors but still hundreds of degrees below freezing.

The 3-D effect that scientists observed in the LCLS experiment, which occurs in a superconducting material known as YBCO (yttrium barium copper oxide), is a newly discovered type of “charge density wave.” This wave does not have the oscillating motion of a light wave or a sound wave; it describes a static, ordered arrangement of clumps of electrons in a superconducting material. Its coexistence with superconductivity is perplexing to researchers because it seems to conflict with the freely moving electron pairs that define superconductivity.

‘Totally Unexpected’ Physics

“This was totally unexpected, and also very exciting. This experiment has identified a new ingredient to consider in this field of study. Nobody had seen this 3-D picture before,” said Jun-Sik Lee, a SLAC staff scientist and one of the leaders of the experiment conducted at SLAC’s Linac Coherent Light Source (LCLS) X-ray laser. “This is an important step in understanding the physics of high-temperature superconductors.”

The dream is to push the operating temperature for superconductors to room temperature, he added, which could lead to advances in computing, electronics and power grid technologies.

There are already many uses for standard superconducting technology, from MRI machines that diagnose brain tumors to a prototype levitating train, the CERN particle collider that enabled the Nobel Prize-winning discovery of the Higgs boson and ultrasensitive detectors used to hunt for dark matter, the invisible constituent believed to make up most of the mass of the universe. A planned upgrade to the LCLS, known as LCLS-II, will include a superconducting particle accelerator.



Science - Three-dimensional charge density wave order in YBa2Cu3O6.67 at high magnetic fields

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Horse park operator tries to calm development concerns as it pursues more covered paddocks

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Equest’s revised development plan for the … [visit site to read more]
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Dallas is ready to pay someone to find out if the city has enough downtown parking spaces

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Does downtown Dallas need more parking? Or less? (G.J. McCarthy/Staff photographer) The question is hardly a new one. But, perhaps, we’ll finally get an answer to a decades-old conundrum in downtown Dallas itself: Is there too much parking, or not … Continue reading
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